Mike is referring to a sequence of sharpening that is sometimes called three-stage sharpening which is popularly associated with the late Bruce Fraser (
http://www.creativepro.com/article/out-of-gamut-thoughts-on-a-sharpening-workflow).  I process my NEF files in Lightroom and apply capture sharpening there (what Mike refers to as restoring the image sharpness at 100% view).  I find that its sharpening algorithm is quite good for this.  I usually use 80 .7 40 40 as a starting point.  I also have some presets from different sources.  I save final files as TIFs in a separate folder titled "Final Prints" and make the prints through Qimage with Smart Sharpening at its default setting.  I also use Qimage to prepare files for printing at Costco using profiles from Dry Creek Photo (
http://www.drycreekphoto.com/icc/).  The results are always outstanding.
You can also try the USM feature in Qimage with the print equalizer for capture sharpening, although I find the results less satisfactory than Lightroom.
- Chris